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主演

Tobey Maguire
Spider-Man / Peter Parker

Kirsten Dunst
Mary Jane Watson

James Franco
Harry Osborn

Alfred Molina
Doc Ock / Otto Octavius

Rosemary Harris
May Parker

J.K. Simmons
J. Jonah Jameson

Donna Murphy
Rosalie Octavius

Daniel Gillies
John Jameson

Dylan Baker
Dr. Curt Connors

Bill Nunn
Joseph 'Robbie' Robertson

Vanessa Ferlito
Louise

Aasif Mandvi
Mr. Aziz

Willem Dafoe
Green Goblin / Norman Osborn

Cliff Robertson
Ben Parker

Ted Raimi
Hoffman

Elizabeth Banks
Miss Brant

Bruce Campbell
Snooty Usher

Gregg Edelman
Dr. Davis

Elya Baskin
Mr. Ditkovitch

Mageina Tovah
Ursula

Daniel Dae Kim
Raymond

Hal Sparks
Elevator Passenger

Joel McHale
Mr. Jacks

Stan Lee
Man Dodging Debris

Kelly Connell
Dr. Isaacs

Brent Briscoe
Garbage Man

Emily Deschanel
Receptionist

Jason Fiore-Ortiz
Henry Jackson

Scott Spiegel
Man on Balcony

Andy Bale
OsCorp Executive

Christine Estabrook
Mrs. Jameson

Molly Cheek
Society Woman

John Paxton
Houseman

Joy Bryant
Woman at Web

Joanne Baron
Skeptical Scientist

Peter McRobbie
OsCorp Representative

Timothy Jerome
Injured Scientist

Taylor Gilbert
Mrs. Watson

Peter Vouras
Stage Manager

Donnell Rawlings
Pizza "Heist" Witness
Zachry Rogers
Boy saved by Spider-Man
Ella Rogers
Girl saved by Spider-Man

Louis Lombardi
Poker Player

Marc John Jefferies
Amazed Kid

Roshon Fegan
Amazed Kid

Brendan Patrick Connor
Theater Traffic Cop

Reed Diamond
'Algernon'

Dan Callahan
'Jack'

Elyse Dinh
Violinist

John Landis
Doctor

Tim Storms
Chainsaw Doctor

Susie Park
Clawing Nurse

Patricia M. Peters
Screaming Nurse

Michael Edward Thomas
Man at Fire

Anne Betancourt
Woman at Fire
Venus Lam
Child in Burning Building

Bill E. Rogers
Fireman

Joe Virzi
Fireman
Tom Carey
Train Conductor
Jopaul Van Epp
Boy with Mask
Weston Epp
Boy with Mask

Peter Allas
Train Passenger

Brianna Brown
Train Passenger

Bill Calvert
Train Passenger

Tony Campisi
Train Passenger

Joey Diaz
Train Passenger

Chloe Dykstra
Train Passenger
Simone Gordon
Train Passenger

Dan Hicks
Train Passenger

Julia Max
Train Passenger
Savannah Pope
Train Passenger

Timothy Patrick Quill
Train Passenger

Jill Sayre
Train Passenger

Rickey G. Williams
Train Passenger

Michael Arthur
NYPD Officer (uncredited)
Frank Bonsangue
Pizza Man (uncredited)

Cindy Cheung
Chinese Daughter (uncredited)

Phil LaMarr
Train Passenger (uncredited)

Calvin Dean
Boomer (uncredited)

Andre M. Johnson
Fireman 2 (uncredited)

Peter Cincotti
Piano Player in Planetarium (uncredited)

Peyton List
Little Girl Playing on Steps (uncredited)

Spencer List
Little Boy Playing on Steps (uncredited)

Troy Metcalf
Blue Collar Guy (uncredited)
Scott Ross
Pedestrian (uncredited)

Bonnie Somerville
Screaming Woman (uncredited)
Wesley Volcy
Columbia University Student (uncredited)

Lou Volpe
Man at Web (uncredited)

Garrett Warren
Bearded Doctor (uncredited)
Joseph M. Caracciolo
Priest at Mary Jane's Wedding (uncredited)
剧情简介
大战绿妖之后,蜘蛛侠帕克忍痛拒绝了他唯一的挚爱玛丽,因为蜘蛛侠的身份会为自己和亲人带来巨大危险,帕克决定独立承担起蜘蛛侠的责任。帕克一直在忙于应付各种挑战:学习超能力的灵活运用;在超级英雄与平凡大学生的双重身份下隐藏自我、小心翼翼地生活等等。帕克对玛丽越来越难以自拔,但是作为蜘蛛侠又不能对玛丽展开心扉。好友哈利因为误会蜘蛛侠而一直处处与其为作对;唯一的亲人婶婶也对蜘蛛侠的真实身份产生了怀疑。同时,新的挑战又出现了:邪恶而强大的章鱼博士。帕克在种种压力下肩负起蜘蛛侠的使命。
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